Rated 4.9 excellent | 221 reviews
Rated 4.9 excellent | 221 reviews
NAD⁺ (oxidized nicotinamide adenine dinucleotide) is a ubiquitous pyridine nucleotide coenzyme that accepts hydride ions in key metabolic pathways—glycolysis, the tricarboxylic acid cycle, and fatty-acid β-oxidation—to generate NADH for ATP production via oxidative phosphorylation. Beyond its redox role, NAD⁺ serves as an essential cosubstrate for NAD⁺-consuming enzymes such as sirtuin deacetylases and poly-ADP-ribose polymerases, thereby regulating gene expression, DNA-damage repair, and cellular stress responses. NAD⁺ availability also modulates mitochondrial biogenesis and metabolic homeostasis through SIRT1-PGC-1α signaling and impacts aging-related processes, as cellular NAD⁺ levels decline with age.
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